BIOL130 Lecture Notes - Hypopigmentation, Endothelin, Neoplasm
28 Jan 2013
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Ncc originate in ridges of neural folds during gastrulation. Coelesce into ganglia migration involves epithelial mesenchymal transition origin = dorsal margin of neural tube, ventral to surface epithelium. How is ncc fate specified? requires signals from ectoderm and dorsal neural tube. Wnt6, bmp early expression of noelin-1 is a determinant of ncc diff. secreted by neural folds and migrating ncc. Cranial ncc: teeth heart septum pharyngeal cartilage cranial nerve conn. tiss. around eye dermis/hypodermis. Cranial/spinal: schwann cells, glial cells melanocytes enteric ganglia arachnoid/pia matter. Spinal: adrenal medulla pre-aortic ganglia dorsal root ganglia (drg) chain ganglia cranial mesenchyme. Grafting experiments: quail neural tube into chick embryos quail: large nuclei chick: small can follow quail ncc migration leads to chimeras, and is evident by pigmentation patterns. Fate map: graft quail neural tube from s5quail to s5chick can determine what structures form from which axial levels fate map. Developmental potentials: graft s5quail to s25chick answers whether axial level determines developmental fate developmental potentials.
