BIOLOGY 2D03 Lecture Notes - Proteolysis, Calpain, Calnexin

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Increase yield but not the rate of folding reactions the folding of proteins: binding to substrate polypeptides is reversible and dependent on atp hydrolysis. Turnover not: degradation occurs continuously over the lifetime of the cell (whether dividing or, best known pathways lysosomal and ubiquitin-mediated, regulation activity of hydrolysis catalyzing enzymes must be tightly regulated. 2 general strategies for regulation: compartmentalization, selective activation lifespan of a molecule half-life. Lipid degradation: the division between degradation and remodeling is indistinct individual lipids can be rapidly remodeled through simple reactions, glycerophospholipids, some degraded in lysosomes, remodeling is the more likely fate. Both fatty acyl chains and headgroups can be exchanged for another. Global properties (size, charge, flexibility, hydrophobicity, folding. Specific sequence or structural motfs (degradation signals: rates can be altered by increasing the activity of a degradation pathway or by exposing a degradation motif.

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