BIOLOGY 2D03 Lecture Notes - Gluconeogenesis, Citric Acid Cycle, Acetyl-Coa
28 Jan 2013
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Document Summary
Lipid mobilization / fatty acid oxidation fat is great as a storage fuel. 9 kcal/g dietary fat chylomicrons (tg"s; made in intestine) liver, fat fat synth in liver vldl to fat. Ffa in adipose liver, muscle, kidneys, heart (not brain, rbc"s) Lipoprotein lipase: chylomicron fa + glycerol (capillary lumen of adipocytes) Mobilization of tg"s from fat tissue: all act to inc intracellular camp. Hsl, perlipin camp also causes translocation of hsl to fat droplet. Ffa"s inhibit hsl insulin activates camp phosphodiesterase dec camp free glycerol must be exported b/c no a-glycerophosphate no tg synth. Occurs in mitochondria of: muscle (heart, skeletal) liver (for ketogenesis: fa activation by thiokinase. R-co2 r-co-amp r-co-scoa: entry into im space by cpt1. **inhibited by malonyl coa (fa synth intermediate) *: entry into matrix by cpt2. Ffa synthesis (high malonyl coa inhibits cpt1) ffa into tg"s vldl liver fasted state: Ffa from fat to liver cpt1/2 translocation into mito b-oxidation .
