5-350 Lecture Notes - Lecture 11: Mef2, Adult Stem Cell, Myosatellite Cell

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Muscle development: there are four muscle types. Classic stuff: review structural and functional differences of the muscle types. Skeletal muscles can specialize; in vertebrates, there are slow and fast twitch. Specialization is due to isoforms of muscle structural proteins. Function of myoepithelial is to expel secretions from various glands and dilate iris of eye. Embryology of muscle on p. 3-4 here (medial to lateral) See lecture 08 on mesoderm formation; details on tissue types that arise are also. Arises from paraxial meso. , divides into sclero-, myo-, dermatome. Somitomeres become somites upon mesenchymal to epithelial transition. First (anterior) 7 remain somitomeres, rest become somites. Myotome gives rise to myogenic cells of the epimere (dorsal, spine extensor muscles) and hypomere (ventral by migration, body wall muscles) Head skeletal: somitomeres and somites of paraxial meso. that migrate to. Limb skeletal: entirely from somites; muscle fate is determine by contact with connective tissue. Cardiac: splanchnic mesoderm around endothelial heart tube.

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