5-350 Lecture Notes - Activin And Inhibin, Kinesin, Bone Morphogenetic Protein 4

• School: University of Windsor
• Department: Biological Sciences
• Course: 5-350
• Professor: Asish Mukhopadhyay

Document Summary

Spatial patterning in vertebrates: a/p patterning (role of hox, previously primitive node was thought responsible, but evidence points to. Ave; hox genes are also important in establishing the a/p pattern: hox gene structure: see lecture 07, esp. collinearity with expression and ra sensitivity, hox code. Theory that the combination of expressed hox genes determines dev. pathway for that region (fewer hox genes expressed anteriorly, more expressed posteriorly) D/v patterning: role of shh in neural tube development. Sonic hedgehog (shh) is expressed in notochord, then in neural floor plate (ventral part of neural tube) Both of these tissues can induce neural floor plate formation. Concentration of shh determines fate of cells (ventral tissues have highest shh exposure: inductive signals in d/v patterning of neural tube. Bmps activate expression of dsl1, also a dorsally expressed gene. On the ventral side, shh acts as the initial inducer family) are candidate dorsal inducers: somite patterning by wnt.