BIOL 2020U Lecture Notes - Thrombosis, Warfarin, Coronary Artery Disease
Document Summary
Reduces levels of antitoxidants (vitamins), more damage due to release of free radials by phagocytes. Nicotine constricts arteries causes platelets to stick together vasoconstriction heart must work harder to force blood through increases blood pressure [exam] Raises conc. of fibrinogen (in blood) increased risk of clotting. Higher blood pressure causes damage to blood vessel lining/endothelium/collagen. [exam: leads to rise on blood platelets and makes them more sticky/form a plug/adhere to collagen fibres, release of thromboplastin/thrombokinase, fibrinogen converted to insoluble fibrin, platelet plug trapped by fibrin mesh. Raises blood cholesterol by causing a rise in ldls in blood. Carbon monoxide reduces the efficiency of the blood in terms of carrying oxygen: haemoglobin combines with co more readily than with oxygen forms carboxyheamoglobin, associated with plaque formation. Principle chd = heart muscle receives inadequate amount of blood or oxygen/(coronary) blood supply reduced.
