BIOL 3010 Lecture Notes - Bone Morphogenetic Protein 4, Runx2, Pharyngeal Arch
29 Jan 2013
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Document Summary
Bone development crest this way) cells then die plate: mechanisms of bone formation. Arises from mesenchyme from lateral plate mesoderm, sclerotome, or neural: endochondral ossification. It is when bone forms from calcification of cartilage (most bone arises. Perichondrium forms around condensation of migrated mesenchymal. Chondrocytes lay down ecm/collagen, mature into hypertrophic form, Tissue is vascularized, osteoblasts come in to lay down bone, get trapped and become osteocytes. Active remodeling: osteoclasts (monocyte lineage) degrade bone and osteoblasts refill it. Defects in osteoclasts can give rise to osteopetrosis. Fos required for osteoclast formation from macrophages. Src required for ruffled borders and bone resportion. In 6th week, standard bone structure arises (diaphysis, epiphysis, growth. Bone is regenerated in adult in same way: membranous ossification. Direct formation of bone, for flat bones of the skull. Embryologic origin of bones: axial skeleton: forms from sclerotome; mesenchymal cells are moved into position where they undergo endochondral ossification, skull.
