BIOL 3010 Lecture Notes - Monocyte, Euchromatin, Megakaryocyte

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Vasculogenesis, angiogenesis, hematopoiesis: vasculogenesis and angiogenesis, vasculogenesis vessels cords mesoderm. Refers to the initial formation of blood vessel in fetus. Splanchnic mesoderm gives rise to angioblasts, which forms blood. In yolk sac, this involves blood islands; in embryo, involves endothelial. Cords coalesce to become primary endothelial plexus: angiogenesis. Refers to remodeling of vasculature, throughout life. Occurs through sprouting, branching, and vascular pruning: molecules involved in blood vessel formation. Fgf is involved in angioblast formation from paraxial and lateral plate. Vegf is expressed by endoderm, and receptors are on angioblasts. Tie1 and tie2 are receptor tyrosine kinases on endothelial cells that involved in recruitment of mesenchymal cells to form smooth muscle layer. Definitive hema. pluripotent stem cells (hpsc) develop in the agm. Prenatal erythropoiesis involves globin switching, which becomes epo dependent in the hepatic stage. Prenatal formation of other white blood cells occurs at various times: hematopoietic pluripotent stem cells.

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