BIOL 3010 Lecture Notes - Semicircular Canals, Oval Window, Fasciculation
29 Jan 2013
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Document Summary
Special senses: eye, ear, and nose: overview of sensory cells of the eye, ear, and nose. Due to evolution, the cilia of sensory cells are on the topographical outer surface of the body. Eye: signal through a 7tm containing rhodopsin, coupled to g-protein; retina is part of the forebrain (diencephalon), lens derives from lens placode of surface ectoderm. Ear: mechanoreceptive cilia directly tranduce vibration to ion channel opening; derives from otic placode of ectoderm overlying hindbrain (rhombomeres. Nose: odorant binds and signals through gpcr/camp; derives from olfactory placode of forebrain (telencephalon) The eye: embryology of the eye choroids, sclera, etc) Optic vesicle derives from neural plate, lens from surface ectoderm. Neural crest and mesoderm contribute to other eye tissues (cornea, Shh splits the eye field by inhibiting eye dev. along the midline. Reciprocal induction: bmp4 and bmp7 from optic vesicle induces lens primordium, and fgf1 and fgf2 from lens induces optic vesicle (eye primordium)
