BIOL 1010U Lecture Notes - Lecture 12: Lysosome, Lymph Node, Mhc Class Ii

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30 Jan 2013
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Dendritic cells (and other antigen presenting cells: overview. Professional apcs are dc, macrophages, b cells; express mhc ii. Dcs are the most efficient apc for primary immune response. Dc life cycle: dc progenitors migrate from bone marrow to peripheral tissues, immature dc"s continually sample environment until ag is encountered. Sampling aided by adsorptive endocytosis using prrs. Regulated: by gm-csf, by lps, tnf, il-1. Sampling of passing t cells; costimulatory molecule expr on dc. Stable interactions form with ag-specific t cells (especially cd4+) Can also activate cd8+ tc cells (superactivated dc), cause th cell differentiation through il-12, activate b cells. May play role in t cell tolerance by presenting ag without signal 2.

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