BIOL 1F25 Lecture Notes - Lecture 18: Pax2, Bone Morphogenetic Protein 4, Glial Cell Line-Derived Neurotrophic Factor
30 Jan 2013
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Document Summary
Ureteric bud from the mesonephric duct invades metanephric mesenchyme and induces nephron formation. Mesenchymal condenses to form blastema, which develops into a primitive nephron in a process that involves reciprocal inductions. Ureteric branching gives rise to the whole complement of nephrons. Blood vessels follow ureteric bud, which allows proper contact at each. Kidney shifts from pelvic region to abdominal region and contacts glomerulus adrenal gland formation development. Genes involved in kidney induction: initiation of duct formation. Lim1: txn factor expr by intermediate mesoderm required for duct. Pax2 and sim1: other txn factors that are also involved. Bmp4 (from ectoderm), ra and activin (somite): specify nephric field: gdnf/ret induces ureteric bud outgrowth, an early step in nephron. Gdnf is a secreted molecule expressed by intermediate mesoderm. Spatial expr of gdnf is determined by wt-1 and pax2 (+) and foxc1 and. Foxc2 (-); also, bmp4 limits ret signaling to caudal region.
