BIO152H5 Chapter Notes - Chapter 13: Model Organism, Chromosome, Genetic Linkage

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rubygnat506

31 Jan 2013

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Mendel discovered that in garden peas, individuals have two alleles, or versions, of each gene. Prior to the formation of eggs and sperm, the two alleles of each gene separate so that one allele is transmitted to each egg or sperm cell. The separation of homologous chromosomes during anaphase of meiosis i explains why alleles of the same gene segregate to different gametes. If genes are located on different chromosomes, then the alleles of each gene are transmitted to egg cells and sperm cells independently of each other. This occurs because chromosomes line up randomly in metaphase of meiosis i. There are important exceptions and extensions to the basic patterns of inheritance that mendel discovered. The cell theory describes the basic structure of organisms. The theory of evolution by natural selection clarifies why species change through time. 1865- gregor mendel worked out the rules of inheritance through a series of brilliant experiments on garden peas.

Related Questions

Which statements pertaining to genetic variability are correct? Check all that apply (note that wrong answers will be deducted from right answers)!

Crossing over is defined by the exchange of chromosome pieces during metaphase one of meiosis.

If a germ cell (i.e. parent cell before meiosis) had only two pairs of homologous chromosomes (i.e. 4 chromosomes total) there are 2 possible combinations of maternal and paternal chromosomes in gametes.

Siblings produced by sexual reproduction are different because sperms are different from one another and eggs are different from one another, and the combination of an egg and sperm is basically unique.

Random fertilization means that all possible combinations of eggs and sperm are equally likely, i.e. it is pure chance which sperm fuses with which egg.

Individual chromosomes contain thousands of genes. This means that during each crossing over event, more than one gene is exchanged between paternal and maternal chromosomes.

limedonkey586

1). Explain the significance of the fact that gametes contain half of the chromosome complement of somatic cells. Tell me something about variation, if you have a sibling (if you don't imagine you do) - how is your sibling's genetic make-up similar and/or different from yours? What about your mom and dad?

2). Explain the terms reductional division and equational division. What is reduced or kept equal? To which nuclear divisions do these terms refer?

3). What is the diploid number (2n = ?) of an organism if it has
a) 12 chromosomes at Anaphase of Mitosis?
b) 12 chromosomes at Anaphase I of Meiosis?
c) 12 chromosomes at Anaphase II of Meiosis?

4). Compare/contrast Metaphase I of Meiosis with Metaphase of Mitosis.

5). What are the two mechanisms of variation in Meiosis, and during which stage(s) does each occur?

6). Draw a diagram of a bivalent and label the following parts: centromere, sister chromatids, non-sister chromatids, homologous chromosomes, chiasma.

7). A diploid cell has 1 pair of acrocentric chromosomes (Chromosome 1) and 1 pair of submetacentric chromosomes (Chromosome 2).
Â· Gene X is on Chromosome 1. Gene Y is on the short arm of Chromosome 2 and Gene Z is on the long arm of Chromosome 2.
Â· The maternal chromosomes have the X, y, z alleles, whereas the paternal chromosomes have the x, Y, Z alleles.
Draw these chromosomes, labeling ALL alleles, as they might appear in Metaphase I of Meiosis.

Ploidy refers to the number of complete sets of chromosomes (genes) present in a cell. The number of chromosomes in a complete set is a fixed characteristic of a species. Humans are diploid with two sets of 23 chromosomes. Fruit flies are diploid with two sets of 4 chromosomes. Sexually reproducing organisms are diploid, each somatic cell of an organism has two complete sets ("di" is a prefix indicating 2.). To complete a life cycle and reproduce new members of a species, mating is required. Mating brings a donation from a male and a donation from a female together. However, if the male and female cells remain diploid, the fertilization will result in a tetraploid zygote. In general, these are not viable. A mechanism is needed to form special haploid cells, gametes. The diploid set is split precisely into two complete haploid sets. That mechanism is meiosis.

The complete set of chromosomes of a species is also the complete set of genes of a species, the genome. (Yes, there is a minor contribution from mitochondria and chloroplasts. Inheritance of this information is "cytoplasmic".)

Please answer the following questions:

1. How many chromosomes in a brain cell of a fruit fly? How many chromosomes are in a liver cell of a human? Explain both answers.

2. How many chromosomes are in a fruit fly unfertilized egg? How many chromosomes are in a human egg? Explain both answers.

3. Why is meiosis necessary for sexually reproducing organisms? How many chromosomes are in a human zygote? Relate the two answers.

4. What is a gene allele? Suppose there is a gene called "bingo" and it is present once in a complete haploid set. How many alleles of "bingo" does a diploid individual have? How many copies or versions of the gene "bingo" are present in a diploid individual?

5. Modern DNA sequencing clearly identifies alleles by showing the different DNA sequence of each allele. These alleles may be termed structural alleles (I coined the term for this problem.). Classical genetics only dealt with phenotypes or visible traits. As a result, alleles of genes were identified by functionality, usually normal or non-functional. Using your knowledge of gene structure and gene expression, postulate a relationship between structural alleles and functional alleles. (include relative amounts; more, less, or equal).

BIO152H5 Chapter Notes - Chapter 13: Model Organism, Chromosome, Genetic Linkage

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