BIOL 1111 Lecture Notes - Nonsense Mutation, Gp41, Conformational Change
1 Feb 2013
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Document Summary
Antibody attached by only one of its multiple binding sites. Generally interferes with attachment of virus to cell surface. High ratio of antibody to virus required neutralization depends: stable neutralization antibody-virion complex does not dissociate readily on saturation. Antibody molecules that bind to 2 sites of the virion greatly increases the stability of the complex. Stable neutralization does not require saturation of the virion surface with antibody molecules single bound antibody sufficient to neutralize. Attachment not prevented instead later step preceeding delivery of the viral genome is affected. Specific mechanisms include alteration of capsid formation preventing release of viral genome or prevention of a conformational change required for delivery of the genome. Vaccines: vaccination generation of antibody mediated and cellular immunity against specific viruses by administration of whole virions or their components only known means of preventing viral diseases. 2 types: whole virus vaccine - pathogenicity must be eliminated while ability to elicit antibody response retained.
