BIOL 1111 Lecture Notes - Phosphoribosyl Pyrophosphate, Biliverdin, Chlorophyll

• School: University of Windsor
• Department: Biological Sciences
• Course: BIOL 1111
• Professor: Habetler

Document Summary

Rds in heme biosynthesis: succinyl coa + glycine ala explains glycine"s long lifespan in vivo. Iron present ibp bound tln can occur similar strategy for ferritin tln. **loss of ibp binding can also destabilize transcripts (transferrin)** regulation: hemin inhibits heme biosynthesis activates globin translation degradation: Rbc destruction releases lots of heme heme biliverdin, bilirubin (yellow) Liver: bilirubin bilirupin diglucuoronide excreted in bile. Pbg deaminase activity deficient + alas activated excess pba/ala neuropathy, psychosis, abdominal pain. Porphyria cutanea tarda uroporhyrinogen decarboxylase deficiency extreme photosensitivity (blistering), hyperpigmentation, facial hair. Erythropoetic protoporphyria deficiency of ferrochelatase photosensitivity, hepatobiliary dysfunction, anemia. Jaundice hyper bilirubinemia neonatal increased destruction of fetal rbc"s. Uv light treatment hepatocellular reduced bilirubin conjugation cannot excrete in bile obstructive conjugated bilirubin cannot be excreted due to obstruction (pancreatic carcinoma) (gall stones) Monoclonal antibodies myeloma cells (hgprt deficient) won"t grow in hat (antifol containing) lymphocytes won"t proliferate (but do contain hgprt) fusion hybrids will grow in hat.