BIO120H1 Lecture 16: BIO241 Lecture 16

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2 Feb 2013
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BIO120H1 Full Course Notes
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We discussed anchoring junctions and how they can overcome the challenges to cell-cell adhesion by clustering and by making linkages to the cytoskeleton. Today we are going into these things in the slide. We will go through a few more types of anchoring junctions, then we"ll talk about occluding junctions and finally communicating junctions. The first anchoring junction he wants to discuss is adhesion mediated by these selectin receptors. So here we have this protein reaching out and binding to sugars or carbohydrates on another cell. It is not like binding like, it is binding to something different, it is binding to a carbohydrate, it is different from the cadherin binding mechanism. This lectin domain then binds to oligosaccharides on other cells & the fact that it is binding to oligosaccharides, so multiple sugars, means that this will have a clustering effect.

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