BIO120H1 Lecture Notes - Aflatoxin, Imatinib, Ames Test

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2 Feb 2013
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BIO120H1 Full Course Notes
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BIO120H1 Full Course Notes
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Today we"re going to discuss cancer & as we can see from these statistics, this is a major issue in society to deal with. The key thing about this slide is that these pathways are also the pathways that are critical for normal cell biology so the same pathways that are involved in normal cell biology are also involved in cancer. They somehow go awry & can lead to cancer. So we can see for example here in this part, we"ve got cadherin integrins, we can see cell-cell interactions can be implicated in cancer. Here we can see pathways downstream of growth factors or mitogens that will lead to the activation of myc & deriving progression through the cell cycle. Here we have control of cell death. Here we have sensors of dna damage and p53. Here we have another pathway related to the cell cycle. So these same pathways that control normal cell biology are implicated in cancer.

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