CSB331H1 Chapter Notes -Hemidesmosome, Atp Hydrolysis, Facilitated Diffusion
2 Feb 2013
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Cadherins mediate ca-dependent cell-cell adhesion in all animals. Cadherins are present in all multicellular animals whose genomes have been analyzed. Other eukaryotes, including fungi and plants, lack cadherins, and they are absent from bacteria and archaea also. Cadherins therefore seem to be part of the essence of what it is to be an animal. Removing ca from the ec medium causes adhesions mediated by cadherins to come adrift. Monoclonal ab were raised against the cells of interest and each ab was tested for its ability to prevent the cells from. Sometimes, esp. for embryonic tissues, this is enough to let the cells be easily separated sticking together again after they had been dissociated. Rare ab that bound to the cell-cell adhesion molecules showed this blocking effect. Virtually all cells in vertebrates and prob in other animals, seem to express one or more proteins of the cadherin family.
