BIOL 2P93 Lecture Notes - Lingual Lipase, Lipid Bilayer, Thoracic Duct
4 Feb 2013
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Document Summary
Introduction: fatty acid classification, long chain 12-18 c, medium chain 8-10 c, short chain 4-6 c. Importance of fats & lipids b: major source of energy (9. 3 kcal/g, absorption of h2o insoluble vitamins, signaling molecules, substrates for synthesis (essential fatty acids linoleic (omega-6) In water seek to hide hydrophobic regions (away from h2o) In apolar solvent hid polar groups i. ii: can self-assemble into complex structures, critical micellar concentration (cmc, lipids are not very soluble in h2o, but over a certain concentration (cmc) they organize into micelles, micelle extremely soluble! Aggregate of monomers in dynamic equilibrium; hides hydrophobic groups. Lipid absorption: challenge: absorbing and transporting hydrophobic/amphipathic molecules in a hydrophilic environment, luminal phase, emulsification by gastric motility. Physical event to generate small fat droplets => sa: lipolysis by gastric lipase. Lingual lipase: cleaves short tgs, only important in infants. Gastric lipase: optimum ph 3-6; frees 1fa from tg; secreted from chief cells: solubilization by bile salts.
