BIOL 2P94 Lecture Notes - Voltage Clamp, Spacetime, Squid Giant Axon

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Membrane potential: fundamental concepts, resting potential is 70 mv, close to ek due to open k+ channels, ion distribution gives rise to different equilibrium potentials via nernst eqn. High na+ outside (ena = 64 mv) , high k+ inside (ek = -86 mv) At steady state, a point depolarization d v is graded: it tails off exponentially according to length scale l. , a measure of the relative resistance of the membrane and axoplasm. Due to resistance (ion channel) and capacitor (neuronal membrane) in parallel, upon current pulse voltage asymptotically increases to steady state value according to time constant t , the product of resistance and capacitance of the membrane: consequences. Since l goes as (cid:214) r, resistance decreases with diameter of dendrite/axon. Spatio-temporal summation: depolarizations nearer axon hillock are more likely to cause action potential, input signal summation requires appropriate timing. Small depolarizations do not result in action potentials due to outward k flow.

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