BIOL 2P94 Lecture Notes - Climbing Fiber, Classical Conditioning, Cerebellum
4 Feb 2013
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This lecture describes a model for how the cerebellum circuitry gives rise to conditioned learning. The basic cerebellar circuit is shown in figure 1 memorize it. It consists of the usual neuronal components, but of added importance is the type of synapses. Pf-pc, cf-pc, and mf-dcn synapses are excitatory, whereas pc-dcn and cf-dcn synapses are inhibitory. The cerebellar circuit can be seen as a negative feedback control loop for motor signaling through the. In the marr/albus model, a mechanism for associative eyeblink conditioning can be directly mapped onto the cerebellar circuit: Disinhibition of the dcn gives rise to the conditioned response. Since ltd of the pf-pc synapse via cf-pc association results in dcn disinhibition, the model proposes that such ltd is the cause of eyeblink conditioning. Appropriate ltd or ltp of other synapses that cause downstream dcn disinhibition may also contribute to learning. There are several lines of evidence that support the marr/albus model:
