BIOL 202 Lecture Notes - Stomach Cancer, Blending Inheritance, Transmembrane Protein

• School: McGill University
• Department: Biology (Sci)
• Course: BIOL 202
• Professor: Daniel Schoen

Document Summary

Law of equal segregation -->inheritance pattern wt single genes chromosomal basisof inheritance patterns. Cdh1 gene-->e-cadherin protein. (used in zonula adherens, it is a transmembrane protein, thats associated with the actin filaments, plays a role in adhesion). When mutated, cells aren"t stuck together as much, cells can move more freely, encouraging metastasis of the cancer. (dominant mutation, in this case) gastric cancer, 1-3% of the time is due to a genetic mutation. If you have a mutation of the above gene, the probability of developping gastric hancer is very high. Esophagojejunostomy, attach the esophagus to the duodenum, make a pouch near the jejunum that sort of replaces the stomach (?) The pt did have cancer, in the end, after looking at her stomach, post removal. Genetics prior to mendel===> blending inheritance (aristotle=mixture of semen and menstrual blood) 2 different types of crosses--> cross pollination and selfing. Cp==> transfer of pollen with a brush, removal of anthers, progeny.