BIOL 2020 Study Guide - Final Guide: Helix-Turn-Helix, Folding Funnel, Protoporphyrin Ix

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11 Feb 2013
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Describe motifs/super secondary structures and give an example. How do we know that the primary sequence codes for the 3d sequence, give example with urea. Describe curves of hemo and myo for oxygen binding. Describe hemo affinity for o2 in the lungs and tissues vs. myo. Globular single polypeptide, oxygen buffer in heart and skeletal muscles, 1 heme group. Particular combinations found in many proteins, e. g. helix turn helix (found in protein that binds dna) Globular units, peptide chains connect them, like pearls on a string. 2 alpha subunits and 2 beta ones, alph2beta2. Urea denatures ribozyme, and when renatured it forms the same disulphide bridges and connections and is enzymatically active, proving the statement. Retain partly correct intermediates because they are more stable, folding funnel shows the breadth of all the possibilities and it shows that there are different pathways to the native structure.