BIOL 2020 Study Guide - Final Guide: Uncompetitive Inhibitor, Non-Competitive Inhibition, Enzyme Catalysis
Document Summary
Describe covalent catalysis, general acid-base catalysis, metal ion catalysis, catalysis by approximation. Equation going up curve and down of optimal ph. Pigment in dark fur, but has low tolerance for heat, thats what cats are dark around paws where the temp is cooler. Binds directly to active site, inhibition relieved by increasing substrate concentration. Only binds when substrate is bound and cannot be overcome by the addition of more substrate. Binds at a different binding site, decreasing the number of active enzyme molecules by changing the shape of the active site, cannot be overcome by increasing amount of substrate. Sulfanilamide is one for paba (metabolite for bacteria in synthesis of folic acid) Km is the same, vmax is lower, dilute solution of enzyme. Competitive: increase km and vmax is the same. Uncompetitive: vmax and km are reduced by equivalent amounts. Noncompetitive: km is the same, and vmax is decreased.
