BIOL 2020 Study Guide - Final Guide: Succinate Dehydrogenase, Isocitrate Dehydrogenase, Succinyl-Coa

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11 Feb 2013
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How does citrate synthase prevent side reactions, stored accumulation. Oxaloacetate+acetyl coa +h2o citryl coa (thio bond) citrate +coa + h+ Ccatalyzes synthethic reaction , 2 units joined without direct use of atp. 49 kd, oxaloacetate binds first (conformational change) and then acetyl. Cannot hydrolyze acetyl coa but can to cirate coa also hydrolysis not in place until citrate coa formed, stored in vacuoles n fruits (0. 3m) accumulation thru mito. Toxin, activated to fluoroacetyl coa, reacts with citrate to become suicide inhibitor of aconitase, shuts down citrate acid cycle, therefore pesticide, Nad and fad come from reduction of o2. Competitive inhibitor for succinate dehydrogenase, competes with succinate. Succinate dehydrogenase has 4 nuclearly encoded subunits, sdha mutation causes e, other 3 cause tumor formation, create superoxide radical. Allosteric control of citric acid cycle: pyruvate dehydrogenase stimulated by pyruvate and adp inhibited by. Atp, acetyl coa and nadh: isocitrate dehydrogenase + from.

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