Microbiology and Immunology 2500A/B Lecture Notes - Inflammatory Bowel Disease, Nod2, Innate Immune System
11 Feb 2013
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Document Summary
Innate immunity is the first line of defense against a pathogen. It is constantly ready to destroy a pathogen. It is effective at stopping the majority of pathogens at an early stage. Properties of innate immunity: it is inherited from your parents we are born with innate defenses. It is well conserved in evolution, in that all humans have the same defenses. It is always initiated when a pathogen contacts the body. It responds immediately to a pathogen and the pathogen is usually eliminated before symptoms arise. Innate immunity has no memory there is the same immune response to identical pathogens with each exposure and it non-adaptive. Innate cells and soluble molecules rapidly eliminate pathogens that enter tissue. If the innate immune system is unsuccessful certain innate cells instruct the adaptive immune system to eliminate the pathogen. Barriers: modes of pathogen entry into the body 1.
