BIOL 3020 Lecture Notes - Extrapyramidal Symptoms, Phenothiazine, Fluphenazine
11 Feb 2013
School
Department
Course
Professor
Document Summary
Most imp develop in the treatment of s was the advent in the 1950s of several medications referred to as antipsychotic drugs. These drugs referred to as neuroleiptics ucxz they produce the side effects similar to the sump of a neurological disease. 1st generation (conventional) antipsychiotic drugs---one of most freq prescribed antipsychiotci drugs in the past 50 yrs was phenothiazine. Use pf antihhsitimanines was produced to reduce surgical shock. New phenothiazine derivative which was called chlorpromazine . this drug proved very effective in. He notices that they made ppl sleepy and less fearful calming ppl with s. By 1970 more than 85% of all ppl in state and provincial mental hospitals in the us and canada were receiving this drug or another phenothiaizne. Also used butyrophenones (haloperidol, haldol) and the thioxanthenes (thiothixene, navene) . these seem to reduce the positive symp of s but have much less effect on the negative symp.
