BGEN 3020 Lecture Notes - Lipid Peroxidation, Posterior Column, Intramuscular Injection

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Fat soluble vitamins: vitamin a, function: is very imp in children for growth and can have failure to thrive in vit. Very important in iodopsin/rhodopsin within the eye and the first sign of vit a def is night blindness which is called nictolopia. Vit a also prevents sq metaplasia: example of vit a def: eye with sq metaplasia, goose bumps on back of arm called follicular hyperkeratois. Eye is lined with cuboidal epithelium; when you get sq metaplasia, will get white spots on the eye. If become extensive, grow over eye, and can lead to softening of the cornea (keratomalacia), and leads to blindness. 2nd mcc blindness globally = vit a def. Mcc blindness globally = trachoma; mcc blindness in usa = diabetes. Increased vit a causes cerebral edema, also get papilloedema (which causes the headache), can alsp lead to herniation and death. There is also an increase of retinoic acid (used from treating acne and acute progranulocytic anemia).

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