BGEN 3020 Lecture Notes - Big Bite, Enzyme Assay, Peroxidase
24 Feb 2013
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Neutrophils when you have acute inflammation = ie appendicitis, neutrophilic leukocytosis, left shift, toxic granulation, and leukamoid rxn. Leukamoid rxn means that it looks like leukemia but it isn"t and it"s benign. You see greater than 30-50,000 cells in the blood. Kids get these a lot (ie otitis media). Adult with otitis med = 12,000; kids with 30,000 (exaggerated). Example: pertussus whooping cough lymphocytosis (60,000) pediatricians are worried about all leukemia, but kid doesn"t have anemia or thrombocytopenia; kid comes in pale, coughing. In atypical lymphocytosis this is a lymphocyte that is doing what it"s supposed to do when presented to and ag. It"s responding to the ag by dividing and getting bigger, so basically it"s an antigenic stimulated lymphocyte. When talking about atypical lymphocyte, the absolute first thing that pops into the mind is: mononucleolosis ebv. Other dz that are seen with large, beautifully staining bluish cells: cmv, toxoplasmosis, any cause of viral hepatitis, phenytoin.
