PHGY 210 Lecture Notes - Lecture 2: Myxedema, Cyclic Adenosine Monophosphate, Pituitary Adenoma
25 Feb 2013
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Document Summary
It is more important to have calcium ions in the blood than in the bone. Negative feedback loop allows for the bone, kidney and gut to release/increase absorption of calcium when parathyroid hormones are secreted. Corticotopin releasing hormone interacts with adrenal glands to form a double feedback loop as glucocorticoid level increases. 2 cell types: anterior and posterior (adenohypophysis and neurohypophysis). Posterior pituitary produces oxytocin and arginine vasopressin, caused by gene duplication diversion, short peptides. Anterior pituitary: dopamine is the prolactin-inhibiting hormone, derived from free tyrosine. Posterior pituitary gland an outgrowth of the hypothalamus, connected by the pituitary stalk. Supraoptic and paraventricular ganglions send down axons in the pituitary stalk and synthesize oxytocin and vasopressin. Prohormones processed while being transported down the axon, by the time it is released, they are mature. Carried by neurophysins with a half life of 1-3 min.
