BIOL371 Lecture Notes - Arachnoid Granulation, Choroid Plexus, Myelin
27 Feb 2013
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Development of human cns 1: 4 weeks. Ant end of neural tube three regions forebrain, midbrain, hind brain: 6 weeks. Cerebrum covers most of other brain region. Organization of adult cns: protection surrounded by bony cage, three layers of ct and csf, ventricles with csf. 2 lateral, 2 descending extend to brain stem. Csf continuous with central canal of spinal cord: csf secreted by choroid plexus. , glucose, ph, rbc, protein: presence of rbc in csf suggests infection. Reabasorbed into venous blood by arachnoid villi. Glial cells of cns: oligodendrocytes white matter (myelin sheath within cns, microglia -> scavengers (phagocytic immune cell, astrocytes regulate ecf via release of chemicals, ependymal create barriers. Bbb: lipid soluble molecules cross easily, hydrophilic only if specific transporters/carriers are present. Aa, ions, peptide/proteins: block drugs and stuff. Neural tissue: unable to switch to anaerobic metabolism. Aerobic only: o2 readily crosses bbb, cns capillaries express high level of glucose transporters, brain.
