BIOL 1500 Lecture Notes - Endoplasmic Reticulum, Nuclear Pore, Nuclear Membrane

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Rna leaves the nucleus after modification, through nuclear pore. Although not evident in this drawing, the er membrane is contiguous with the nuclear membrane and surrounds the nucleus. Once the mrna has left the nucleus, it will be bound by the small and large ribosomal subunits! Er lumen or into the lumen and the er membrane. Video http://www. youtube. com/watch?v=xclfdgbysaa&feature=related: or if there is no signal sequence the polypeptide is translated on free ribosomes i the cytosol. Inside the er lumen, the proteins are folded with the help of chaperone proteins (ie. bip). This means, the proper bonds (hydrogen, ionic, disulphide) are made between the proper amino acids on the polypeptide chain. Also, on the proteins that require sugar modification (mainly cell membrane proteins) the basic sugar (oligosaccharide) unit will be attached to the polypeptide in the er. The folded proteins leave the er in a vesicle and head to the golgi.

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