REN R360 Lecture Notes - Isotopes Of Iron, Nuclear Power Plant, Acute Radiation Syndrome

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yellowmoose652

4 Mar 2013

School

University of Alberta

Department

Renewable Resources

Course

REN R360

Professor

Melanie Muise

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Document Summary

There are 2 different kinds of health effects: stochastic effect humans exposed to long term, lower level of radiation. This is most problematic because it is very hard to detect and to know what will happen to our health after long time exposure to lower level of radiation. What is known is that if the amount of radiation increases the severity of this affect will not change and will stay the same and the type of illnesses will be the same. But the risk to get that illness will increase. This amount of radiation is proven to cause cancer. Cancer is uncontrolled growth of cells (any kinds of cells as there are many kinds of cancers). Naturally in our physiological functions, our cells divide and produce new ones to replace old ones. This natural physiological process is controlled by our genetic material. But if certain radiation disrupts this natural process, it will cause cancer.

Related Questions

While the concepts of screening and surveillance are intertwined there are subtle distinctions between the two ideas. The main goals are data collection to measure magnitude, changes, and trends in populations. The objective is to create interventions in defined populations. On the contrary, testing to identify individuals with infection or disease is the main goal of screening. The area of breast cancer screening and breast cancer surveillance has been a point of contention. Please read the following article and weigh in on which side seems most convincing:

There is a heated debate in this country about the risks and benefits associated with screening mammography. Proponents on both sides of the debate feel equally as strongly for or against annual breast cancer screening. Despite oneâs opinions regarding the utility of screening mammography, it is difficult to deny that the rates of false-positive exams, the rates of overdiagnosis, and the cost of annual screening are too high. We can do better. It is time to stop devoting energy to arguing about data from studies performed decades ago and start working toward gathering new evidence. In late 2015, we will initiate the WISDOM study to investigate the safety and effectiveness of a personalized breast cancer screening model. This model will use a comprehensive risk assessment process to determine individualized screening regimens for women in the interventional arm. The data collected in this study will better inform the screening debate and will allow us to shed more light and less heat on the issue.

There is a great debate in this country about the risks and benefits of screening mammography. On one side of the debate are those in favor of the one-size-fits-all model of performing annual mammograms starting at the age of 40 for women who are not known to be at greatly elevated risk of developing breast cancer. The radiology community argues that this model reduces the rates of interval cancers, aids early detection, and should not be changed. On the other side of the debate are those who support the United States Preventive Services Task Force (USPSTF) recommendations to screen women biennially starting at age 50, and to screen women in their 40s based on personal preferences regarding the potential benefits and harms of screening.¹ Specialists on this side of the debate believe that annual screening results in unacceptably high rates of false-positive recalls, overdiagnosis, and overtreatment.

Recently, the USPSTF published a draft update to the 2009 breast cancer screening recommendations, and the debate has once again intensified. The solution to this problem is not to continue the debate with repetitious reviews of studies that were performed more than 30 years ago, but to focus ahead on how to make breast cancer screening safer and more effective. The time has come to put the debate to rest by conducting a modern-era screening trial.

Before focusing on the future, let us first take a moment to review the current state of breast cancer screening in the United States. The majority of providers in this country continue to recommend annual screening starting at age 40.² Proponents of annual screening mammography cite a resulting relative reduction in breast cancer mortality of 21%, which is based on data from randomized screening trials performed in the 1970s and 1980s.³ However, this estimated benefit comes with significant drawbacks. After 10 years of annual screening, over one-half of women screened will receive a false-positive recall, and 7% to 9% will undergo a benign biopsy.^4,5 False-positive recalls and benign biopsies can cause long-lasting psychological distress that can negatively impact a womanâs willingness to undergo screening for breast cancer in the future. Additionally, false-positive recalls and overdiagnosis cost the United States an estimated $4 billion per year,⁶ and screening in aggregate is estimated to cost between $8 and 10 billion per year.⁷ This estimate is based on a screening mammogram costing between $135 and $195. If the cost of mammography increases, the overall cost of breast cancer screening increases proportionally. As a country and as healthcare professionals, we can and should do better.

Breast cancer screening should harness the advances that have been made in breast cancer risk assessment and our understanding of breast cancer tumor biology. Screening should be more effective at finding relevant and consequential cancers, and should result in fewer benign biopsies. Screening should also be better integrated with prevention. Lastly, screening should be more cost-effective. A personalized screening model could potentially achieve all of these goals.

The aim of a personalized screening model would be to focus resources on those women who are most likely to benefit. The foundation of the model would be a comprehensive risk assessment that would take into consideration a womanâs classical risk factors for breast cancer, such as her personal and family history of breast disease. This comprehensive risk assessment would also include an evaluation of breast density and germline genetic testing. These risk factors would then be placed into a breast cancer risk model that would estimate the womanâs 5-year risk of developing breast cancer, and personalized screening recommendations would be made according to this risk. Women at high risk of developing breast cancer would be screened more frequently, and women at low risk would be screened less frequently. This risk estimation could also be used to make recommendations regarding chemoprevention, thereby integrating screening and prevention, which is the real key to reducing mortality from breast cancer.

This model has the potential to optimize the benefits of mammography in the context of modern systemic therapy while minimizing harms. Using a similar risk model in 3 independent study populations, it has been shown that 50% of cancers occur in women with the top 20% predicted risk.⁸ This model is also practical because these risk factors are easy to assess, and it is estimated to be more cost-effective than annual screening, despite the use of genetic testing, which has decreased in cost significantly since the Supreme Court ruling in June 2013 that stated that the human genome could not be patented.

Personalized screening may be the way forward, but this can only be determined in the setting of a randomized controlled trial. In the fall of 2015, a randomized controlled trial comparing personalized breast cancer screening with annual screening will be initiated within the Athena Breast Health Network that spans the University of California and the Sanford Health system in the Midwest. This study will be called the WISDOM study (Women Informed to Screen Depending on Measures of Risk). We have received a large grant from the Patient-Centered Outcomes Research Institute to perform this trial, and are also working with payers and self-insured employers, such as Blue Shield of California and UC Health, to create a Coverage with Evidence Development policy that will cover the medical costs of the trial. Using surrogate endpoints and long-term follow-up, we aim to determine whether personalized screening is as effective, less morbid, more preferred by women, and enables prevention more as compared with annual screening. Our hope is that this trial will provide us with the information we need in order to determine the safest and most effective way to screen women for breast cancer. Then, and only then, will we be able to put âThe Great Mammography Debateâ to rest.

As we move toward a more biology-based approach to the treatment of diseases, our approach to screening for and preventing those diseases should follow suit. The opportunity before us is to learn who is at risk for which type of breast cancer, and to optimize our screening and prevention strategies for each individual according to her personal risk. Over the last 20 years, many advances have been made in our understanding of the risk factors that contribute to a womanâs risk of developing breast cancer. The time has come for us to harness this knowledge and apply it in an evidence-generating fashion to shed more light and less heat on the screening controversy.

Do you believe that US Preventive Services Task Force (USPSTF) recommendations should be followed or do you believe screening should start at age 40? Why or why not?

Can anyone help me with the following questions, it is due tonight and im having a hard time figuring most of these out and in-between a couple of answers. Thanks!

1. Which of the following is the PRIMARY goal of risk assessment?

A. maximize profit

B. balance risks and benefits

C. reduce liability

D. determine lethal doses

2. The probability of an adverse outcome based on the exposure and potency of a hazardous agent is known as the:

A. toxicity

B. risk

C. hazard

D. margin of safety

E. therapeutic index

3. Risk Assessment includes all the following, except:

A. risk characterization

B. exposure assessment

C. dose-response assessment

D. hazard identification

E. cost-benefit analysis

4. The process of making risk information understood by local officials, community groups and other stakeholders is known as:

A. risk management

B. risk characterization

C. risk communication

D. risk perception

E. risk estimation

5. The Hazard Identification step in the risk assessment paradigm may include which of the following:

A. in vitro testing

B. structure-activity relationships

C. animal bioassays

D. epidemiologic data

E. all of the above

6. A basic premise of carcinogen risk assessment is that:

A. surface area is proportional to body weight

B. chemicals that cause tumors in animals will cause tumors in humans

C. all dosing regimens are equivalent

D. all animal strains are relevant

7. The Point of Departure (POD) for a low-dose extrapolation could be which of the following:

A. NOAEL

B. LOAEL

C. BMDL

D. none of the above

E. all of the above

8. The benchmark dose (BMD) approach is preferred over the NOAEL/LOAEL approach for all the following reasons, except:

A. the full dose-response curve is considered

B. it includes a measure of variability

C. the same benchmark response be used across studies

D. it results in lower reference values

9. A biochemical change, functional impairment, or pathologic lesion affecting an organismâs performance, and reducing its ability to respond to environmental challenges is known in risk assessment as the

A. point of departure

B. benchmark dose

C. adverse effect

D. carcinogenic effect

10. When there is a cancer risk of 1 in 10,000, this is considered to be of

A. high concern

B. moderate concern

C. somewhat low concern

D. no concern at all

11. Which toxicant is commonly found in indoor air due to off-gassing of plywood and furniture?

A. arsenic

B. lead

C. methylene chloride

D. dioxin

E. formaldehyde

12. Which if the following was NOT an event in the United States that triggered widespread awareness of environmental issues in the 1960s?

A. Relocation of families from Love Canal in Niagara Falls, NY

B. Cuyahoga River catching on fire in Ohio

C. Publication of Silent Spring by Rachel Carson

D. Nationwide federal ban of smoking cigarettes in bars and restaurants

13. The study of the fate and effects of chemicals in the environment is the definition of: A. Environmental toxicology

B. Ecotoxicology

C. Environmental health toxicology

D. Risk assessment

14. An example of an area source of air emissions would be:

A. A volcano

B. A moving car

C. A gas station

D. A power plant

15. Which of the following is considered to be âgood up high and bad nearbyâ?

A. Ozone

B. Carbon monoxide

C. Carbon dioxide

D. Sulfur dioxide

16. Which of the following water disinfectants is safest from the perspective of not producing any known DBPs?

A. Chlorine

B. Chloramine

C. Ozone

D. UV

17. The most significant anthropogenic source of carbon monoxide would be classified as a:

A. Point source

B. Area source

C. Mobile source

D. Natural source

18. According to Genius (2006), what do some scientists believe is the most frequent cause of childhood cancer and leukemia?

A. Pharmaceuticals in drinking water

B. Exposure to diuretics in utero

C. Prenatal exposure to carbon monoxide and other industry emissions

D. Neonatal exposure to polyvinylchloride (PVC) plastic

19. In the Genius (2006) article, what did the scientists who published in the journal Science discover about the possible transgenerational impact of exposure to environmental toxicants in pregnancy?

A. Epigenetic mechanisms may permanently alter the germ-line and genetic traits of offspring of an exposed individual

B. Epigenetic changes die out after three successive generations of offspring

C. Epigenetic changes only occur when a toxicant is an endocrine disruptor

D. Epigenetic changes never take place when the toxicant is a pesticide or fungicide

20. According to the article by Chemnick and Climatewire (2013), âSoggy Vancouver Island in British Columbia has become an unlikely new home for Cryptococcus gattii, a tropical and subtropical yeast-based fungus.â What health effect does this yeast-based fungus have on humans when it is inhaled?

A. None

B. Triggers asthma attacks

C. Causes a kind of meningitis

D. Eventually leads to lung cancer

greykangaroo345

PLEASE ANSWER ALL QUESTIONS..PLEASE NOT ONLY 1 QUESTION. THANK YOU

QUESTION 1. Chronic diseases generally have several underlying characteristics, including a.A long latency period between exposure to risk and disease outcomes b. Low degree of preventability c. High curve rate d.None of the above

QUESTION 2.Which of the following risk factors collectively explain a significant proportion (not incidence) of most chronic diseases. a.Tobacco, alcohol, diet b.Tobacco, alcohol, diet, physical activity c. Alcohol, physical activity d.Tobacco, diet, physical activity

QUESTION 3.Adherence to treatment is influenced by several interacting dimensions including a.Social and economic factors b. Healthcare system factors c.Condition-related factors d.Therapy-related factors e.Patient related factors f.All of the above

QUESTION 4. _________ is the leading cause of cancer in both developed and developing countries worlwide a.Radiation exposure b. Tobacco use c.Pesticide exposure d.Air pollution

QUESTION 5.This week's YouTube video on treating non-communicable diseases in Rwanda showed how a community health worker helps to treat heart disease, diabetes and _______ a.Cancer b.Asthma c.Hepatitis d.HIV/AIDS

QUESTION 6.Which of these are myths of chronic disease control a.Benefits of chronic disease control accrue not only to the individual but also to the population b.Economic growth improves all health conditions c. Chronic diseases are associated with low SES/poverty d.Chronic disease only occurs in the elderly e.a and c f.b and d

QUESTION 7 ___________ remains the leading cause of death among both men and women in low- and middle-income countries a.Cancer b.Cardiovascular disease c. Diabetes d.Obesity e.Respiratory disease

QUESTION 8.Chronic disease in adults accounts for approximately 60% of all deaths worldwide. True False

QUESTION 9.The WHO's Innovative Care for Chronic Conditions Framework includes a positive policy environment. True False

QUESTION 10.It is estimated that the overall number of cancer cases will rise by 50% in the next 20 years. True False

QUESTION 11.Comorbidity refers to simultaneous occurrence in a person of two or more disorders; comorbid conditions can increase the risk of adverse outcomes. True False

QUESTION 12.Emerging evidence supports starting promotion efforts during pregnancy and early childhood and continuing efforts throughout life lower exposures to major chronic disease risk factors. True False

QUESTION 13. Increased cumulative exposure to risk factors over the lifecourse combined with social and economic inequalities, leads to the levels of inequalities seen in later adult life. True False

QUESTION 14.The "compression of morbidity" model proposes that morbidity due to aging cannot be postponed or mitigated by disease prevention programs True False

QUESTION 15.There is few significant funding sources for chronic diseases in low-and middle-income countries. True False

QUESTION 16.To combat chronic diseases, modern, evidence-based interventions emphasize shared decision making and collaborative goal setting among providers and patients. True False

QUESTION 17.In the absence of legislative, financial and engineering approaches, health education programs often have a limited impact on preventing or reducing chronic diseases. True False

QUESTION 18. It is estimated that deaths from diet-related chronic disease in China will triple between 1995 and 2025. True False

QUESTION 19.The third highest percent of global DALY's is attributed to which risk factor? a.Alcohol use b.Tobacco use c.Unsafe sex d.Childhood underweight

QUESTION 20.In the 1990's which country experienced a substantial decline in male life expectancy as a result of dramatic socio-political changes a.China b.Russia c. India d.Canada

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REN R360 Lecture Notes - Isotopes Of Iron, Nuclear Power Plant, Acute Radiation Syndrome

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