Biology 1002B Lecture Notes - Lecture 17: Cell Nucleus, Helix-Turn-Helix, Gene Duplication
15 Mar 2013
School
Department
Course
Professor
Document Summary
Lecture 17: development: posttranslational regulation controls mrna availability to ribosomes. Changes in pre-mrna processing: alternative splicing remove diff combinations of exons and introns creating family of proteins. Masking proteins bind to mrnas and make them unavailable for protein synthesis. Rate of mrna breakdown: steroid hormone slow or increase rate. If 5"utr is transferred from one mrna to another, the half-life is the same. Controlling sequences in 5" utr of mrna recognized by proteins that regulate stability. Regulation of expression by small noncoding single stranded rna interference (rnai) bind to mrna. Identify the various mechanisms for regulating the activity of proteins after they are translated. Rate of translation = rate of protein synthesis. Adjusting length of poly a tail increases translation. Viruses suicide (damaged, infected, don"t want to infect others and more beneficial to die) Cannot support itself due to surface area and volume ratio: mechanism of plasmid toxin/antitoxin system as a possible origin for cell death genes.
