HTHSCI 3I03 Lecture Notes - Lymphopoiesis, Paratype, Immunoglobulin Heavy Chain

• School: McMaster University
• Department: Health Sciences
• Course: HTHSCI 3I03
• Professor: Jonathan Bramson

Document Summary

B-cell= in bone marrow (generates bcr)= negative selection= leaves bm as immature b-cells. Either becomes plasma cell or memory b-cell. In periphery= becomes activated= mature b-cell (effector b-cells) Everything starts as multipoitent progenitor cells: either become common lymphoid progenitor (gives rise to b cell) or common myeloid, remember common lymphoid progenitor pro-b-cell mature b-cell. Stomal cells=non-lymphoid= form adhesive contacts with the b-cell: source of cytokines/chemokines involved with b-cell differentiation. B-cell maturation (we only talk about b-2 cells in lecture) Becomes late b-cell gives large pre-b-cell small pre-b-cell immature b-cell matures. Note: heavy chain rearrangement always occurs first (always start with dj) Dj arranges first on heavy chain and the v to dj occurs when this occurs it forms the heavy chain (mu heavy chain) If successful= get mu chain expressed as pre-b-cell receptor: need to be expressed along with a surrogate light chain (lambda 5 or vpreb, note the surrogates do not need to, triggers light chain rearrangement.