HTHSCI 3I03 Lecture Notes - Immunoglobulin Class Switching, Somatic Hypermutation, Cd154
16 Mar 2013
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T-cell help= causes somatic hypermutation (affinity maturation) and isotype switching. Going to get plasma cells or memory cells (i. e. maturation) following proliferation. Thymus dependent= t-cell help, mhcii required: co-stimulation ( signal 2 )= coming from the t-cells, protein antigens and maybe carbohydrates, somatic hyper-mutation (more igg produced because remember that the initial ab produced is igm), isotype switching. *** note: cd40l/cd40 interaction is important for b-cell survival! B-cells can only be recognized by t-cells that recognize the same antigen. I. e. the epitope that the t-cell receptor recognizes should be bound by the. Tag a tentanus taxoid protein (toxin of a bacteria that has been neutralized) link to a polysaccharide. Will have protein and polysaccharide bound to mhcii. T-cell will come along and recognize the b-cell. I. e. can easily vaccine against the taxoid protein: get b-cell response to the polysaccharide (i. e. encapsulated bacteria are now bound by ab!!) Blue= paracortical area= t-cell zone (physical separated from b-cells)
