BIOB11H3 Lecture Notes - Lecture 10: Lac Operon, Lac Repressor, Cyclic Adenosine Monophosphate
Document Summary
Lecture 10 gene regulation i: promotors and control circuits. Sps: figs 12-27, 28, 29, 32, 40, 44. Vocabulary:operon/regulatory gene/repressor/inducer/co-repressor/derepression/positive vs. negative control/cis vs. trans acting factors/deletion mutant/enhancer. There are two distinct parts of an operon (shown in green). The first part is called the regulatory gene which encodes a repressor protein. The repressor protein governs the activity of the operon by interacting with the operator (o) sequence. The second part of the operon comes after the promoter (p) region and the operator sequence, where there are several genes in a row all involved in controlling the same biochemical pathway. When the regulatory gene is active, it makes a repressor protein which may or may not interact with the operator and depending on that interaction, it either helps to turn the gene on or turn the gene off. Now, let"s talk about the lac operon by talking about lactose metabolism. Lactose is a disaccharide made of galactose and glucose.
