Biology 1002B Lecture Notes - Lecture 18: Maturation Promoting Factor, X-Inactivation, Xist (Gene)
19 Mar 2013
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Document Summary
Which of the following sequences is transcribed but not translated: er target sequence, sd box, enhancer, terminator, 1, 2 & 3, 2 & 4, 1&3, 4 only, all. X chromosome inactivation creates genetic mosaics: x-linked genes (dependent on which x is activated) Xp is preferentially silenced in some tissues imprinting: ex. placenta. Shutting off x: chromosomes that are loose and available are more likely to be transcribed, tightly pact rna (xist x inactive specific transcript) binds along the x chromosome & most genes. Associated with x and shuts down transcription of x: affects the whole chromosome (unlike other epigenetic mechanisms) In canada, men are at higher risk for cancer than women. Leading cuase of premature death in canada. 40% of women & 45% of men will develop cancer. 25% of canadians can expect to die of cancer. Can inherit predisposition to cancer not the actual cancer. Oncogenes mutations in these genes cause cancer.
