KINE 4516 Study Guide - Midterm Guide: Cytochrome C Oxidase, Atp Synthase, Cytochrome C1
19 Mar 2013
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Increase in mito= biogenesis and function leading to positive health effects. Less biogenesis and dysfunction causes increase in apoptosis, decrease in energy supple, and. This can be caused by aging (which decreases mito content and function, and disease which can be metabolic, neurodegenerative, cardiovascular, and muscular) Of diseases= alzheimer"s, type 2 diabetes, als, mitochondrial myopathies, huntington"s, cancer. Mito theory of aging= free radicals cause aging. 2 main factors= absolute count of mito and function of mito. Microtubules move the mitochondria around the cell. Muscle reps about 40% of body mass in non obese individuals. Fibre type is determined by myosin (the isoform) thick filament. Thin filament contains the actin, troponin, and tropomyosin. Troponin has 3 different binding sites (tropomyosin, calcium, and actin) Peripheral nuclei are on the edge of the fiber, if they are in the middle it is a sign of injury. Muscle fibers are long multinucleated cells, packed with myofibrils.
