BIOB11H3 Lecture Notes - Iron Response Element, Histone Acetyltransferase, Cpeb
Document Summary
Transcription factors have both dna binding and activation. They have binding domain and transcription factors that can turn on genes or repress it. So one allows for it to bind for the right sequence and one affects its function. In the major groove of the helix scructure allows for nucleic acids to be more easily accessible. Within that major groove, the nitrogenous bases are easily accessible. Major ones: zinc finger tf will form a loop facing the major groove. The helix loop helix transcription factor bind as dimers, usually in the form as heterodimers. Leucine is found on every 7th amino acid. The leucine motif is to zip up the interaction between the molecule is to shield themselves from the water. This motif is used in the bzip factor. For microarray, you get a robot that samples all genes. Another robot uses a printing process to print spots on a solid surface.
