BIOC33H3 Lecture Notes - Third-Degree Atrioventricular Block, Heart Failure, Coronary Circulation

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20 Mar 2013
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Coronary artery blood flow occurs mainly during diastole. The reason for this is that during systole, when the heart is contracting, it compresses some (large portion) of the coronary arteries and completely occludes them and thus coronary blood flow decreases to the cardiac muscles. In mammals, the heart muscle has to be supplied with blood through coronary arteries. The afterload is the pressure that the ventricles must work against during the ventricular ejection phase of the heart cycle (into systemic circulation). It is equal to the aortic blood pressure. When the afterload increases, the stroke volume decreases. On the left side of the heart, the afterload is the pressure from the aorta and on the right side, the afterload is the pressure from the pulmonary arteries. A decrease in arterial pressure (afterload) leads to a marginal decrease in edv but a substantial decrease in esv.

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