CSB332H1 Lecture Notes - Lecture 14: Raphe Nuclei, 5-Ht1A Receptor, Autoreceptor
22 Mar 2013
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Suppose you"re a member of a clinical team composed of psychologists, psychiatrists, and social workers. And a patient is suffering from major depression and is not responding to any anti depressant treatments. Drug x has a very slow onset of action (regular treatment for a month/two months before improvement occurs) Drug y is very fast and kicks in 1 hour after 1 injection but some serious side effects such as sleep walking with strange behavior (possibly violent during the sleep walk) Consider risk of suicide of the patient. Dangerous to use both because of drug interactions; possible but studies must be done first. Problem with treating depression: really slow; a month to kick in. There are very fast acting anti depressant the first one that was used: take only a few mins, amphetamine very effective, side effects: very addictive, could lead to psychosis and other emotional stresses. Examine the brain of a depressed individuals.
