BIOL 2021 Lecture Notes - Lecture 3: Cell Membrane, Proteoglycan, Phospholipid
14 Apr 2017
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Figure 10-15: asymmetry of plasma membrane (pm, outside ptd-cho, sphingos, all glycolipids, inside ptd-ser (- charge), ptd-etm. Charged inside: cholesterol evenly distributed, flip-flip easily, functions of asymmetry of pm. Proteins (protein kinase c) bind to specific lipids on cytosolic side. Lipid head groups generate signals: inositol phospholipids as example. Ptd-ser used in apoptosis: death signal from outside so neighboring cells will come eat them. Membrane proteins (other half of membrane by weight other half is lipids: 30% of animal genome codes for membrane proteins, different membranes -> different proteins -> different functions, proteins can be from 25%-75% of membrane weight. Myelin of neurons (ex) electrical insulation, 25% protein. Mitochondrial inner membrane (ex) 75% protein electron transport, atp synthesis: protein association with membranes. Figure 10-17 (important figure) ways proteins associate with lipid bilayer. Membrane proteins (a: 1, 2, and 3 are transmembrane proteins (goes through and sticks out of membrane)
