Microbiology and Immunology 3300B Study Guide - Final Guide: Tnf Receptor Associated Factor, Interleukin 8, Irf7
29 Mar 2013
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Gram (+) peptidoglycan, strong wall consisting of lipids/proteins/sugars ex/ lipoteichoic acid. Gram (-) lipopollysacharide; 2 outter membranes; very narrow band of peptidogycan. Not always on the outside; on the inside bacterial dna is cpg dna not methylatd on the c like ours is (to be repaired). Beta glycan is on the side; sugar that can be a pamp. Tlr3 binds dsrna virus - nk cells: discuss the tlr signal pathway. Ligand binds and dimerizes; binds myd88 and mal, recruits irak1 and irak4, Itrak phosphorylates traf, trica ubs traf and nemo, tab1/2 and tak complex get phosphorylated by irak, binds nemo, tak ph. Ikb goes to get degraded and releases nfkb which goes to produce cytokines: not all receptors are the same. Instead of using myd and mal either use trif or myd dsrna tlr3 recognizes; trif activates tbk1 which phos. Nods are a form of tlr that are within the cell. Mannose receptor binds carbs of bacteria and fungi.
