MIMM 214 Lecture Notes - Lecture 32: Immunity (Medical), Somatic Hypermutation, Memory T Cell

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Second spike: early reinfection handled by preformed abs/effector t cells from the previous response - not considered a memory response. Third spike: late (in years) reinfection handled by immune memory b/t cells: this is the memory response - a larger response as well. In the secondary response the innate response is not necessary for the adaptive response to occur (but there is still some innate activity: memory is not present in innate immunity. In practical terms, resistance to a particular infectious disease upon re-exposure to the microbe that causes that disease after having had that disease once before: or after being vaccinated. The differences between primary and memory responses are: more abs, more cells, different abs, different lymphocyte features (higher affinity) Features of immunological memory: easier to detect/monitor for b cells than t cells, mediated by a small and steady number of memory cells, some of the proliferating at a given time, previous ag exposure required.

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