BIOL 200 Chapter Notes - Chapter 4: Secretion, Beta Cell, Exocytosis

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17 Apr 2017
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In this topic we examine the 2 major pathways that newly synthesized proteins will take: the secretory pathway (aka exocytosis) and the lysosomal pathway. As discussed in the previous topic, each golgi stack has two faces, the cis face and the transface. The flow of material in the golgi apparatus is from cis to trans. Transport vesicles from the er containing membrane and soluble proteins fuse with the cis face of the golgi. Proteins then move from the cis cisternae, to the medial, then to the trans citsernae. As the proteins move along they are sorted, based on a combination of the chemical features of the protein itself, and there is an increase in the acidity inside the golgi as the protein moves from cis to trans. From the trans golgi network (tgn), there are 2 main destinations, via 3 distinct pathways:

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