BIOC13H3 Lecture Notes - Lecture 18: Malate-Aspartate Shuttle, Malate Dehydrogenase, Dynamin-Like 120 Kda Protein

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17 Apr 2017
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There are 2 shuttles that can bring nadh into the matrix. G3p shuttle system is the first shuttle. In the cytosol you find an enzyme called g3p dehydrogenase, it oxidizes nadh and pass e on to dihydroxyacetone phosphate, which is an intermediate of glycolysis, forms g3p. There"s an enzyme on the outside face of the mitochondrial membrane, a mitochondrial version of the same enzyme, carries out same reaction. Major difference is that mitochondrial version will use fad as its electron acceptor, rather than nad, making fadh. Then enzyme will pass electrons from fadh to ubiquinone in the membrane and from there the electrons are passed to the rest of the electron chain. The electrons from nadh have entered the etc but the physical nadh has not. Nadh, fadh and q have different reduction potentials. Fad has a higher more positive reduction potential than nadh.

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