MCB 2000 Lecture Notes - Lecture 31: Pyrophosphate, Lanosterol, Lipoprotein Lipase
Document Summary
Cholesterol will not be on this exam. Where most fatty acid synthesis after a meal happens. Adipose tissue does some, mostly in the liver. Triglycerides are very hydrophobic -> must be packaged in lipoproteins. Cholesterol is amphipathic -> will be used by many tissues. Very low density lipoprotein (vldl) will transfer newly synthesized triglycerides, is made in the liver. Fat in the diet is packaged as a triglyceride. Lipoprotein lipase -> activated by insulin, in capillary walls. Fatty acids will be split off glycerol backbone -> will be taken up by skeletal muscle and oxidized for energy, or will be reesteri ed in the adipose (will link fatty acids back to glycerol backbone) Glycerol will recycle back to the liver, liver has glycerol kinase, will add a phosphate, glycerol phosphate will be used for attaching fatty acid after cleaving phosphate or will keep phosphate.