MCB 2050 Study Guide - Final Guide: Copii, Arf1, Rcc1

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Lamina a not being anchored results in diseases (ex. There will be +ve aa upstream of transmembrane domain and ve aa downstream of domain: charge repulsion causes flip of terminus in translocon and n-term emerges into the cytosol. If not proper, uggt can stick a glucose on the protein and calnexin sequesters it again to refold. If you"re a(cid:374) i(cid:374)tegral (cid:373)e(cid:373)(cid:271)ra(cid:374)e protei(cid:374) (cid:449)a(cid:374)ti(cid:374)g to lea(cid:448)e er (cid:449)ill ha(cid:448)e eres: eres binds to sec24, now you are concentrated into copii vesicle. Golgi: as proteins make their way through golgi, they will encounter different enzymes in a sequential manner. If protein has signal patch (stretch of aas) at the golgi, your sugars are tagged with m6p, to be targeted to lysosomes. If no signal patch, you are destined for the extracellular space: once you are at the tgn, you might belong in tg cisternae so you get packed in a copii vesicle.