BIOL 1119 Lecture Notes - Lecture 32: Sympathetic Nervous System, Sodium Chloride, Collecting Duct System

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Gfr: the amount of filtrate formed per minute by both kidneys. Only small portion of this filtrate is actually eliminated as urine. Must be precisely controlled to ensure proper filtration and reabsorption. Controlled to ensure proper filtration and reabsorption: renal autoregulation: 2 important mechanisms (local level nephron, sympathetic control (many nephrons at once, hormonal mechanism: renin and angiotensin (bp) In general: dilate afferent arteriole and/or constrict efferent arteriole. Increase pressure in glom increase gfr increase bp. The ability of nephrons to adjust their own blood flow and gfr locally without external control. Increase local bp = stretches aa (snap back when stretched), aa constricts in response. Increase gfr back up to normal: high gfr causes high tubular flow rate in dct: more sodium past mascula dense: detects as high flow, mascula densa releases different paracrine, which causes jg cells to contract which constricts aa.

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