NURS 2004 Study Guide - Final Guide: Inotrope, Verapamil, Peripheral Edema
28 Apr 2017
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Document Summary
Group of upper gi disorders characterized by varying degrees of erosion of gut wall (common in lesser curvature of stomach and duodenum). Develop when any region is exposed to acid"s pepsin and when an imbalance exists between mucosal defensive factors and aggressive factors. Drugs do not alter the disease process, they create conditions conductive to healing. Moa: suppresses secretion of gastric acid by blocking h2 receptors on gastric parietal cells of the stomach, thus decrease both the volume of gastric juice and decrease hydrogen ion concentration. Early h2 receptor antagonist was cimetidine (tagamet) had more side effects due to distribution. Moa: undergoes conversion to its active form within parietal cells of the stomach. It causes irreversible inhibition of h-k atpase, the enzyme that generates gastric acid. They alter ph which affects dissolution and absorption of other drugs. Moa: prevents nsaid induced gastric ulcers by serving as a replacement for endogenous pgs.
